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Public Citizen argues in a recent article in The Lancet that GlaxoSmithKline GSK ; manipulated data in a clinical study of its asthma drugs Serrvent salmeterol xinafoate ; and Advair fluticasone propionate salmeterol xinafoate ; to downplay their risks. The bill, known as the Fair Access to Clinical Trials FACT ; Act, would require drugmakers to submit clinical trial results to an electronic database or face stiff monetary fines. The proposal, S. 470, has been stalled in the Senate Health, Education, Labor & Pensions Committee since it was introduced Feb. 28 by Sens. Chuck Grassley R-Iowa ; and Christopher Dodd D-CT and tamoxifen. 3 to 16 days ; pharmacy manuf by glaxo wellcome serevent aer.
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ADAM F. SZCZAWINSKI 1913-2006 ; Adapted from: Turner, Nancy J. 2006. Adam F. Szczawinski, A Botanical Pioneer in British Columbia. Davidsonia Upcoming issue. ; Adam Szczawinski was born on October 21, 1913 in Lwow, Poland. He attended the University of Lwow from 1932 to 1937, where he studied botany and medicine. In 1936, he became a lecturer in biology at the Commercial College in Lwow, and in 1937, an instructor at the University of Lwow, until 1939 when World War II broke out. He was forced to flee Poland and enlisted in the Polish Army in France on January 4, 1940. He fell in love with and married Mary, his beautiful Scottish wife, and together they emigrated to Canada in 1948. He received his Ph.D. through the Department of Botany, at the University of British Columbia, in 1953. He was UBC's first PhD recipient in botany. After completing his PhD, he remained as a lecturer in the Department of Botany at UBC until 1955, when he took the position as Curator of Botany and Head of the Botany Division at the British Columbia Provincial Museum [now Royal British Columbia Museum] in Victoria. Mary gave birth to their only child, their son Alan, in 1956. Tragically, in 1968, when Alan was only 12 years old, Mary died suddenly from a heart attack; Adam never remarried. Together with Dr. V. J. Krajina and others, he conceived and implemented the Ecological Reserves program in British Columbia. As well as recruiting authors for several of the handbooks, he personally authored and coauthored several of Handbooks as well as coauthoring the Flora of the Saanich Peninsula with A. S. Harrison ; . After his retirement in 1975, he continued to give many public lectures, especially on edible mushrooms and co-authored five additional books. Adam Szczawinski passed away peacefully at Victoria General Hospital on June 2, 2006. Until the time he entered the hospital, he lived in his own home, the one he and Mary had purchased when they moved to Victoria, on Viaduct Avenue. He is survived by his son, Alan Szczawinski, daugher-in-law Barbara Lund, and grandchildren Jacob, Maxwell and Kira. Eminent North American mycologist, Orson K. Miller, Jr. passed away June 9, 2006. : ou cas botany-micro ben ben364 8.
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Competition Pharmaceuticals The pharmaceutical industry is highly competitive. GlaxoSmithKline's principal competitors are large international pharmaceutical companies with substantial resources. Some of these companies and their major products are mentioned below. Medicines may be subject to competition from different therapies during the period of patent protection and, once off patent, from generic versions. The manufacturers of generic products typically do not bear research and development costs and consequently are able to offer their products at considerably lower prices than the branded competitors. A research and development-based pharmaceutical company will normally seek to achieve a sufficiently high profit margin and sales volume during the period of patent protection to repay the original investment and to fund research for the future. Competition from generic products generally occurs as GlaxoSmithKline's patents in major markets expire. In response, GlaxoSmithKline undertakes a range of activities, including: introducing innovative products into as many markets as possible accelerating the process by which new products are brought to market increasing brand share among customers. Ultimately, GlaxoSmithKline believes that its competitive position is dependent upon the discovery and development of new products, together with effective marketing of existing products. Within the pharmaceutical industry, the introduction of new products and processes by competitors may affect pricing levels or result in product replacement, and there can be no assurance that GlaxoSmithKline's products may not become outmoded, notwithstanding patent or trademark protection. In addition, increasing government and other pressure for physicians and patients to use generic pharmaceuticals rather than brand-name medicines may increase competition for products that have gone off patent. CNS disorders Major competitors to Paxil in the US selective serotonin reuptake inhibitor SSRI ; market are Prozac from Eli Lilly, Zoloft from Pfizer and Forest Laboratories' Celexa. The success of Seroxat Paxil has made it a target for generic manufacturers, against whom GlaxoSmithKline continues to respond appropriately see note 31 to the Financial statements, `Legal proceedings' ; . Imigran has grown to be one of GlaxoSmithKline's leading products through addressing the previously unmet needs of migraine sufferers. Although other companies have launched competing products, newer formulations of Imigran, such as the nasal spray, and the introduction of Naramig have helped GlaxoSmithKline to retain its lead over its competitors in the migraine market. Respiratory Growth of GlaxoSmithKline's newer respiratory products, Flixotide, Seregent and the recently launched Seretide, have continued to drive growth in this market. The established products such as Ventolin and Becotide have faced generic competition for some years but have maintained significant sales. A major competitor to GlaxoSmithKline's respiratory products is Singulair from Merck.
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