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The statins are the most widely used, and also the most powerful medications for lowering ldl cholesterol. Abdominal cramps OBG-5.456. Which of the following therapeutic methods should be applied for controlling bleeding in juvenile metropathia? A ; curettage B ; hysteroscopy C ; hormonal chemical ; abrasion D ; suction curettage E ; no therapy is necessary, as this condition is transitory and selflimiting OBG-5.457. Which of the following drugs is inappropriate for chemical ; hormonal abrasion? A ; ethinylestradiol Mikrofollin ; B ; norethisteron Norcolut ; C ; lynestrenol Orgametril ; D ; methylestrenolon Orgasteron ; E ; progesterone Glanducorpin ; OBG-5.458. Pubertal dysmenorrhea is caused by: A ; the vigorous contractions of the uterine musculature and blood vessels B ; uterine hypoplasia and a narrow cervical canal C ; emotional factors, increased sensitivity to pain D ; all of the above E ; only answers A ; and B ; are true OBG-5.459. Which of the following may cause vaginal discharge of non-infectious origin in puberty? A ; estrogen deficiency B ; psychogenic factors C ; sideropenia D ; all of the above E ; only answers A ; and B ; are true OBG-5.460. Why does adnexitis develop only rarely in gonorrheal vulvovaginitis contracted in puberty? A ; the alkaline pH of the vagina a consequence of low estrogen effect on the vaginal epithelium ; does not facilitate bacterial growth B ; immature endocervical glands are unsuitable for bacterial colonization C ; symbiosis with Dbderlein's bacteria is a prerequisite to the growth of gonococci and due to the absence of estrogen effect, these bacteria are missing from the vaginal flora at this age D ; the course of the infection is the same in all age groups OBG-5.461. Why does Trichomonas vulvovaginitis develop only rarely before pubes A ; there is no occasion for infection to occur B ; the vaginal environment influenced by the effects estrogen is unfavourable for bacterial growth C ; ' the vaginal environment influenced by the lack of estrogen effects.
This effect can be inhibited or reversed by either estradiol benzoate or progesterone. Otc safety tips with more than 100, 000 otc medicines on the market today, you need to be very aware of what you're taking, and as always talk to your doctor or pharmacist if you have questions or concerns, because estradiol transdermal. The Journal of Immunology of endometrial cancer. Thus, it has opposing effects on estrogen dependent growth; it operates like an ER antagonist in the breast yet as an ER agonist in the endometrium. Raloxifene, like estrogen, supports the maintenance of bone density and is used for the treatment of osteoporosis. In addition to this agonistic effect in bone, clinical trials showed that raloxifene treatment decreased the incidence of both breast and endometrial cancer, suggesting that it acts as an ER antagonist in the breast and the endometrium. Thus raloxifene may be an attractive alternative to tamoxifen for the treatment of breast cancer, and the ongoing Study of Tamoxifen and Raloxifene STAR ; trial is directly comparing the efficacy of these two SERM for breast cancer prevention. Despite the widespread clinical application of tamoxifen and raloxifene, very little is understood about how they might affect the function of ERexpressing immune cells. Several studies indicate that SERM influence multiple aspects of the immune system. SERM have been shown to modulate a number of pro- and anti-inflammatory cytokines 18 21 ; . Furthermore, in vivo exposure of mice to tamoxifen 22 ; or raloxifene 23 ; reduced lymphoid organ weights suggesting that these SERM may dampen immune responses. In agreement with this idea, raloxifene negatively regulated B lymphopoiesis in BM in two separate studies 24, 25 ; , and tamoxifen treatment was shown to reduce the severity of autoimmune disease in mouse models 18, 22, 26 ; . However, the observation that tamoxifen has beneficial effects on autoimmune disease are contradicted by data suggesting that tamoxifen can augment lymphocyte activation 22, 27 ; . Regardless, because ER are expressed by many cells of the immune system, including DC 28 31 ; , should not be surprising that SERM possess immunomodulatory properties. There is now a growing body of evidence to suggest that estrogens can directly affect the development and performance of APC reviewed in Ref. 9 ; supporting our hypothesis that SERM also may affect DC differentiation or function. Two studies have shown that the SERM, tamoxifen and toremifine, between 5 M and 5 mM inhibited the GM-CSF- and IL-4-supported differentiation of human DC from peripheral blood monocytes and synovial fluid macrophages 28, 32 ; . Differentiation of monocytes in the presence of these two SERM resulted in fewer cells expressing the DC marker, CD1a, and the DC that did develop exhibited impaired maturation in response to LPS and TNF- as evidenced by significant inhibition of HLA-DR and CD83 up-regulation. The DC also were impaired in their ability to produce biologically active IL-12 following CD40 ligation and to stimulate the proliferation of allogeneic PBMC. Based on competition experiments with 17- estradiol E2 ; , it was concluded that SERM were not operating through ER because E2 was not found to counteract the inhibitory effects of SERM on DC phenotype. Our own studies have shown that the development of murine bone marrow-derived DC BMDC ; from GM-CSF-stimulated precursors in vitro was promoted by the presence of E2 in the culture medium 31 ; . Differentiation of BMDC from E2-supplemented cultures was inhibited in the presence of a molar excess of the full ER antagonist, ICI 182, 780, and tamoxifen. In contrast to the aforementioned studies, our data indicated that tamoxifen acted via ER to inhibit DC differentiation. The reasons underlying this disparity are unclear but might be related to differential requirements for E2 of human monocytes and murine BMDC progenitors. These studies illustrate the potential for SERM to affect immune responsiveness through modulation of DC yet there have been no reports on the effects of raloxifene in this regard. To determine whether raloxifene acted like tamoxifen to inhibit DC differentiation and function, we compared their effects on DC generated in vitro from murine bone marrow progenitors in the presence or.
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Equally as important, side effects that interfere with our ability to think and function should not be regarded as an acceptable trade-off for reducing our symptoms and famotidine. Do approximately lean or soup medications without consulting your phase british. Advantages. Mirena's delivery of progesterone to the endometrium results in less bleeding than with copper IUDs.44 Some women, however, may have irregular bleeding during the first 3 to 6 months. After that, bleeding usually declines, and 20% of women have amenorrhea by the end of the first year. The decreased bleeding profile and 5-year efficacy of Mirena make it an attractive option, especially for women with menorrhagia or those who desire long-term contraception. EMERGENCY CONTRACEPTION Postcoital emergency ; contraception is defined as the prevention of pregnancy within 72 hours of unprotected intercourse or failure of a contraceptive method eg, a broken condom ; . Even though emergency contraception is known to be effective and has a low potential for adverse effects, many patients are not prescribed it because their physicians either do not know about it or are not comfortable with its use. Until recently, the most commonly prescribed regimens included: Ethinyl estradiol 2.5 mg twice a day for 5 days Ethinyl estradiol 100 g and levonorgestrel 0.5 mg, repeated in 12 hours Levonorgestrel 0.75 mg, repeated in 12 hours. Recently, the FDA approved two emergency contraceptive kits. The Preven kit contains a pregnancy test to exclude pregnancy before taking the pills, which each contain ethinyl estradiol 50 g and levonorgestrel 0.25 mg. The patient takes two pills and another two in 12 hours. The Plan B kit is similar, but contains progestin only, thus causing less nausea and vomiting than regimens that also contain estrogen.45 One tablet of Plan B should be followed by a second dose within 12 hours. These regimens have similar efficacy, reducing the number of pregnancies by 89%; however, if Plan B is taken in the first 24 hours, it can prevent 95% of expected pregnancies and fexofenadine.

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Plasma clearance values for norethindrone and ethinyl estradiol are similar approximately 4 l hr. Be able to describe the vomit. For nausea WITH NO VOMITING, eat small frequent meals use dry bland foods - toast, salt biscuits use plain foods broth, yogurt avoid drinking liquids with meals use cold foods - ice cream and cereals take anti-nausea medications as prescribed and pseudoephedrine. It is also known that doses of estradiol can induce a conditioned food avoidance and a conditioned place aversion.
Adamson, G. M., and Billings, R. E. 1992 ; . Tumor necrosis factor induced oxidative stress in isolated mouse hepatocytes. Arch. Biochem. Biophys. 294, 223229. Beutler, B., Milsark, I. W., and Cerami, A. C. 1985 ; . Passive immunization against cachectin tumor necrosis factor protects mice from lethal effect of endotoxin. Science 229, 869 871. Bouwens, L., and Wisse, E. 1992 ; . The origin of Kupffer cells and their anatomic relationship to hepatocytes. In Hepatocytes and Kupffer Cell Interactions T. Billiar and R. D. Curran, Eds. ; , pp. 4 19. CRC Press, Boca Raton. Brown, A. P., Harkema, J. R., Schultze, A. E., Roth, R. A., and Ganey, P. E. 1997 ; . Gadolinium chloride pretreatment protects against hepatic injury but predisposes the lungs to alveolitis following lipopolysaccharide administration. Shock 7, 186 192. Calcamuggi, G., Lanzio, M., Dughera, L., Babini G., and Emanuelli, G. 1992 ; . Endotoxin tolerance and polymyxin B modify liver damage and cholestasis induced by a single dose of alpha-naphthylisothiocyanate in the rat. Arch. Toxicol. 66, 126 30. Chamulitrat, W., Jordan, S. J., and Mason, R. P. 1994 ; . Nitric oxide production during endotoxic shock in carbon tetrachloride-treated rats. Mol. Pharmacol. 46, 391397 and finasteride.
Maier & Hienert 1988 ; used 150 mg testolactone day in combination with 30 mg tamoxifen day and compared the results with those of only 30 mg tamoxifen day. The increase in sperm density was significant in both groups, but no improvement of the other ejaculate parameters was seen in either groups. The incidence of gravidity was the same being 15%. This study confirmed that testolactone prevents elevation of estradiol levels during monotherapy with tamoxifen. Inister for health and social services in wales, brian gibbons, pictured with helen suter, pharmacy supervisor, visited the port talbot lloydspharmacy to see lloydspharmacy's screening service for type 2 diabetes and flagyl.

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227251 20 February, 2003 Class 5. Dietetic substances adapted for medical use; nutritional and dietetic food products for use in body maintenance and weight control, including meal replacements and nutritional drinks in powder mix and liquid form. Meat, fish, poultry and game; meat extracts; preserved, dried and cooked fruits and vegetables; jellies, jams, fruit sauces; eggs, milk and milk products; edible oils and fats. Coffee, tea, cocoa, sugar, rice, tapioca, sago, artificial coffee; flour and preparations made from cereals, bread, pastry and confectionery, edible ices; honey, treacle; yeast, baking powder; salt, mustard; vinegar, sauces condiments spices; ice. Mineral and aerated waters and other non-alcoholic drinks; fruit drinks and fruit juices; syrups and other preparations for making beverages. Entertainment; sporting and cultural activities. Providing of food and drinks and fluconazole.

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Richard Levine, MD is a faculty member at West Jersey-Memorial Family Practice Residency Program. inusitis is a condition that affects 30-35 million Americans and accounts for over 25 million office visits. With direct costs of $2.4 billion per year, and an additional $1 billion for surgical costs, it is a huge problem. Sinusitis is the third most common diagnosis for which an antibiotic is prescribed. Even though most physicians agree that antibiotics are over-prescribed, 50% of patients are given an antibiotic when seeing the doctor for cold-like symptoms. To review, sinus health depends on mucous secretion of normal viscosity, volume, and composition; normal mucociliary flow to prevent mucous stasis and subsequent infection; and open sinus ostia to allow adequate drainage and aeration. Not only do sinuses provide mucous to the upper airways for lubrication and to trap viruses, bacteria, and foreign material, but they also give characteristics to our voices, lessen skull weight, and are involved in olfaction. Why do people with upper respiratory infections complain of sinus infections? The most likely explanation is that the sinus mucosa is contiguous with the nasal mucosa, so that people with a cold feel pressure and congestion in their sinuses. Further confounding the diagnosis of an acute bacterial sinusitis are allergic symptoms. People with allergic rhinitis tend to suffer from nasal congestion, clear rhinorrhea, itching red eyes, and possibly a nasal crease. Distinguishing viral rhinosinusitis from bacterial sinusitis is more difficult. Bacterial sinusitis can be classified into four categories: Acute Bacterial lasts four weeks, symptoms resolve completely Subacute Bacterial begins at week 4, lasts up to 12 weeks Chronic symptoms last more than 12 weeks Recurrent Acute episodes lasting fewer than 4 weeks, separated by at least 10 days, or 3 episodes in 6 months While a viral URI tends to be worse at the beginning of the illness and last no more than 10 to 14 days, a bacterial sinus infection persists for more than 10 days. Although not very specific, physical findings include mucopurulent nasal discharge, swelling of the nasal mucosa, sinus pain, and possibly periorbital swelling. A history of "double sickening, " in which the symptoms were getting better after a few days and then became severe again often points to a bacterial sinus infection. The objectives of treating a bacterial sinus infection are to decrease the recovery time, prevent chronic disease, decrease exacerbations of asthma, and to do so cost-effective way. Antihistamines are recommended if there is an allergic component to the sinusitis, while topical and or oral decongestants can help with the symptoms of congestion. Keep in mind that nasal decongestants, while helpful, should only be used for three or four days to prevent rebound congestion. Nasal irrigation may be helpful but is not done in the majority of primary care offices. Guaifenesin, at a dose of 200mg to 400mg every six hours, might help symptoms as well. Finally, if indicated, an antibiotic may be prescribed. The decision to use an antibiotic is still controversial, since many cases of clinically diagnosed sinus infections are viral and the literature is still reluctant, for instance, norgestimate ethinyl estradiol. CLINIC VISITS - The co-payment for each visit to a clinic is $3.00. Visits to clinics for mental health services, developmental disabilities mental retardation services, alcohol and drug abuse services, Tuberculosis Directly Observed Therapy, family planning and Methadone Maintenance Treatment Programs MMTP ; do not have a copayment. PRESCRIPTION DRUGS - The co-payment for each new prescription and each refill for a brand-name drug is $2.00. The co-payment for each new prescription and each refill for a generic drug is $.50. There is no co-payment for certain drugs to treat mental illness or tuberculosis. Your pharmacist can tell you if there is a co-payment for the drug you need. NONPRESCRIPTION DRUGS - The co-payment for each new order and each refill for a nonprescription over-the-counter ; drug is $.50 and galantamine.

Hopes." Hitchings and Elion shared the Nobel Prize in 1988 with a third scientist, Sir James Black, who also worked for a GSK predecessor company. Black did seminal work leading to beta-blockers for cardiovascular disease and to H 2 -antagonists for peptic ulcers. On the occasion of the awards, he noted his "enduring belief that our brains work best when doing focuses our thinking." Altogether, GSK has five Nobel Laureates in its heritage. The other two are John Vane, for research into prostaglandins among his other achievements, he clarified the way aspirin works ; and Sir Henry Dale, for discoveries about the chemical transmission of nerve impulses. Vane received the award in 1982, Dale in 1936. 4 5 St. Clair does research in the Center of Excellence for Drug Discovery-- Infectious Diseases, GSK. Acute lymphoblastic leukemia ALL ; is a cancer of the blood and bone marrow. Certain immature cells in the marrow proliferate in an uncontrolled manner rather than develop into normal white blood cells called lymphocytes. These immature cells, or lymphoblasts, do not combat.
J. DYER, 1 I. S. WOOD, 1 A. PALEJWALA, 2 A. ELLIS, 2 AND S. P. SHIRAZI-BEECHEY1 1 Department of Veterinary Preclinical Sciences, The University of Liverpool, Liverpool L69 7ZJ; and 2 Department of Medicine, Royal Liverpool University Hospital, Liverpool L7 8XP, United Kingdom and glibenclamide. Feeney CL; Roberts NJ; Partridge MR Do medical outpatients want 'out of hours' clinics? BMC Health Serv Res 5 1 ; 47Rippon I; Lewison G; Partridge MR Research outputs in respiratory medicine. Thorax 60 1 ; 63-67 Coker RK; Shiner R; Partridge MR Update on BTS BLF UK Flight Outcomes Study Thorax 60II10-II11 Smith SF; Brenton H; Roberts NJ; Partridge MR Computer assisted learning is a useful tool to teach final year medical undergraduates the principles of spirometry Thorax 60II59-II59 Roberts NJ; Robinson D; Partridge MR Difficult asthma in the UK: A national survey of approaches to management and available services Thorax. It is with great pleasure and a sense of excitement and anticipation that I set out to write this, my first editorial as your new Editor-in-Chief. While our sights are set firmly on the future, let us first take a brief glimpse into the past. I recently read through the bound copies kept in IDF's Brussels office of the first year's issues of News Bulletin, as our magazine was originally called. In 1954 the contributors included many of our diabetes heroes Elliott Joslin, R D Lawrence and Charles Best, for example. Amongst the many interesting things in that volume, one sentence struck me as a particularly pertinent description of what Diabetes Voice should aspire to do. R D Lawrence writes of News Bulletin being established "to let all countries know what other countries are doing and so to link more closely and more frequently the activities of the whole international movement". This statement, written just over half a century ago, can still serve as a summary of what we wish to achieve with Diabetes Voice. We are all part of this impressive "international movement" and will all benefit from the links that the magazine can forge and maintain. We will benefit immensely from knowledge of what others are doing to make the world a better place for people with diabetes. Diabetes Voice will continue to provide up-to-date, relevant and, on occasion, inspiring `global perspectives on diabetes'. I take over as the most recent in a line of distinguished, hard-working and innovative Editors-in-Chief. My immediate predecessor, Philip Home, will be a hard act to follow. He contributed greatly to the quality, interest and scope of the material contained in Diabetes Voice. One of my main goals will be to maintain this level of quality, scope and interest so that people feel eager to read the magazine as one means of keeping up with developments in the diabetes world. I hope, also, that people will feel inspired to write for Diabetes Voice to inform people around the world about what they are doing perhaps in difficult and demanding situations. Among the immediate past, current and future authors of Diabetes Voice will be some of the future heroes and heroines of diabetes. The editorial team at IDF and I are working with a new designer and publisher. Despite this, you will not notice any fundamental changes in the look of Diabetes Voice. A revision of the layout may well take place in a year or so, perhaps to coincide with the World Diabetes Congress in 2006. In this issue, the articles range geographically from Bolivia to Trinidad and Tobago, from Rwanda to India. They cover topics as diverse as psycho-social care and osteoporosis. They include what will be one of our regular topics this year the diabetic foot and a regular topic for this year and next the 19th IDF World Diabetes Congress in Cape Town. Rhys Williams is Professor of Clinical Epidemiology at Swansea University, UK. He is a VicePresident of IDF and Chair of the Federation's Task Force on Public Awareness and glucovance and estradiol, for instance, rstradiol dosage.

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We investigated whether estdadiol can prevent the ischemia-induced release of cytochrome c from mitochondria and inhibition of mitochondrial respiration in Langendorff-perfused female and male rat hearts. We found that pre-perfusion of hearts with 100 nM 17-estradiol significantly reduced 60 min ischemia-induced loss of cytochrome c from mitochondria in both female and male hearts. Estrwdiol also reduced inhibition of mitochondrial state 3 respiration rate oxidizing pyruvate and malate caused by 60 min ischemia in hearts from both animal genders. Therefore, prevention of loss of cytochrome c from mitochondria by 17estradiol may be one of the possible mechanisms by which estrogens preserve myocardial cell viability during ischemia in both genders. Key words: estrogens, heart, ischemia, mitochondria, respiration, cytochrome c.
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4 2-methoxyestradiol, an endogenous estrogen metabolite, induces apoptosis in endothelial cells and inhibits angiogenesis: possible role for stress-activated protein kinase signaling pathway and fas expression.

Box 3.7: Trade Margins to Pharmacists Statistics reveal the high level of trade margins, which pharmaceutical companies give to pharmacists. Cipla reportedly sells a strip of 10 pills of its painkiller Nicip to the retail dealer at Rs. 2 a strip. The retailer then sells it to the customer at Rs. 25 at a profit of 1, 150 percent. According to information provided by Business World, Ranbaxy's anti-allergic Stanhist costs retailers Rs. 1.80 a strip. This is sold to the customer at Rs. 26. Web information provides further accounts of huge trade margins. A few instances would be as follows: 10-tablet strip of Methygin costing Rs. 5.75 sells at Rs. 54, Nimesulide in a 10-tablet strip costing Rs. 1.85 sells at Rs. 10. The following chart by NPPA gives further conclusive data in the matter of massive trade margins to pharmacists. Company Brand Price printed on the Purchase price of strip retailers Ranbaxy Stannist 26 1.80 Cadila Healthcare Ceticad 26 1.60 Lyka Labs Lycet 25 1.44 Wockhardt Setride 25.2 1.70 Cipla Cetcip 27.5 2.00 Ranbaxy Pyrestat-100 25 1.50 Lupin Lupisulide 24 1.94 Welcure Drugs Omejel Caps 33 4.50 Wockhardt Merizole-20 39 6.48 All figures in Rs.

The 1999 Bangkok Symposium on HIV Medicine. A total of 280 participants from India, Indonesia, Malaysia, Philippines, Taiwan and Thailand. Lectures provided by faculty from Thailand, the U.S.A., Australia and the Netherlands. Introduction Member Prescription Benefit Pharmacy and Therapeutics P&T ; Committee 2 how to use This Preferred drug guide . Cost index generic substitution dispensing limits alphabetical list of drugs . you cannot find the drug on this list it typically means that the drug is non-Preferred, for example, estradiol weight gain!

We are excited about the progress we have made in growing our proprietary business. Less than six years after initiating activities in this area, we have a growing proprietary products business with significant future potential. We currently have 13 proprietary products on the market, five of which we actively detail to physicians. We have four proprietary product applications pending at the FDA and seven in clinical development, one of which is in Phase III studies. We are committed to consolidating our leadership position in women's healthcare, as well as pursuing additional therapeutic categories. Our pipeline includes products in female healthcare, including oral contraceptives, hormone therapy and our transvaginal ring technology products; oncology; urology; and anti-infective anti-viral products. Our SEASONALE extended-cycle oral contraceptive, which created an entirely new category when launched in October 2003, continues to gain market acceptance. Since launch, nearly 1 million prescriptions have been filled. We will expand this product franchise following the approval of our SEASONIQUE product and are working with the FDA regarding issues raised in the Approvable letter. We have also filed a NDA for the SEASONALE Lo levonorgestrel ethinyl estradiol tablets 0.1 mg 0.02 mg and ethinyl estradiol tablets ; extended-cycle oral contraceptive. In the area of hormone therapy, we are building a full line of tablet strengths for our EnjuviaTM Synthetic Conjugated Estrogens, B ; product. Enjuvia is a plant-derived, synthetic conjugated estrogen product that contains a blend of the ten estrogenic substances found in the brand Premarin. This year, the FDA approved our application for the 0.3 mg and 0.45 mg tablets and had previously approved our 0.625 mg and 1.25 mg tablets. We are awaiting the approval of the 0.9 mg tablet strength. Although we were disappointed with the FDA's Not Approvable letter, which we received in April 2005, for our application for our BijuvaTM Synthetic Conjugated Estrogens, A ; vaginal cream, we continue to work closely with the Agency and we are confident the outstanding issues can be resolved. Bijuva, if approved, is intended as a local treatment for vaginal atrophy and famotidine. Ethinylestradiol with levonorgestrel and ethinylestradiol with norethisterone are representative combined oral contraceptive preparations. Various combinations can serve as alternatives Tablets, ethinylestradiol 30 micrograms, levonorgestrel 150 micrograms Tablets, ethinylestradiol 50 micrograms, levonorgestrel 250 micrograms Tablets, ethinylestradiol 35 micrograms, norethisterone 1 mg. 16 : epa.gov nerlesd1 chemistry pharma critical.

8 17 beta-estradiol increases calcium content in fetal mouse parietal bones cultured in serum-free medium only at physiological concentrations.

Estradiol appears necessary in the maintenance of the oocytes in the ovary. 227. NOVEL PROBES FOR THE ESTROGEN RECEPTOR-LIGAND BINDING DOMAIN ER-LBD ; : SYNTHESIS AND EVALUATION OF 17 -E-PHENYLVINYL ESTRADIOL AMIDES. Emmett McCaskill 1, Richard B. Hochberg 2, and Robert N. Hanson 1. ; Department of Chemistry and Chemical Biology, Northeastern University, 102 Hurtig Hall, 360 Huntington Avenue, Boston, MA 02115, Fax: 617-373-8795, r.hanson neu , r.hanson neu , 2 ; Department of Obstetrics and Gynecology, Yale University School of Medicine As part of our program to probe the ER-LBD we have prepared a family of ligands based on the 17 -E-phenylvinyl estradiol scaffold. Previous studies demonstrated that the substituted phenylvinyl estradiols not only possessed significant receptor affinity but also were full estrogens in vivo. In this study we have prepared a new series of estradiol deriviatives in which the phenyl substituent is further functionalized through an amide linkage to a second aromatic group. The new compounds, prepared in high yields via Stille coupling reactions were evaluated for their biological activity. This work has been supported in part by PHA RO1 CA81049 and DAMD17-99-1-9333.

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