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Date: 06 01 05ISR Number: 4678259-5Report Type: Expedited 15-DaCompany Report #200511752GDDC Age: 65 YR Gender: Female I FU: F Outcome Dose Duration Hospitalization Initial or Prolonged Other PT Amnesia Antipsychotic Drug Level Above Therapeutic Blood Creatinine Increased Confusional State Drug Interaction Metabolic Encephalopathy Speech Disorder Therapeutic Agent Toxicity Report Source Product Ketek Lithane Altace Synthroid Zdvair Role PS SS C Manufacturer Aventis Pharmaceuticals Inc. Route.
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Treating both HIV and TB, it is recommended that treatment of these patients be directed by, or conducted in consultation with, a physician with extensive experience in the treatment of these diseases. Patients suspected of having active TB should be placed on appropriate medications as soon as possible, and infection control measures, such as isolation of the patient, should be followed as is appropriate. Most of the basic information regarding active TB is covered in Section 3, "Active Tuberculosis, " of this manual. Please refer to that section which will in most cases apply to HIV-positive as well as HIV-negative individuals. The following is additional information that pertains to HIV infected and in some cases HIV noninfected ; individuals with concurrent active TB and aldactone.
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Organizations Supporting Access to Therapeutic Cannabis 1 ; AIDS Action Council - 1996 2 ; Alaska Nurses Association - 1998 3 ; Alaska Voters - 1998 4 ; Alliance for Cannabis Therapeutics 1981 5 ; + American Academy of Family Physicians 1989, 1995 6 ; American Civil Liberties Union ACLU ; 7 ; American Medical Students Association - 1993 8 ; American Preventive Medical Association 1997 9 ; + American Public Health Association APHA ; - 1995 10 ; Arizona Voters - 1996 & 1998 11 ; Berkeley, CA - 1979 12 ; Breckenridge, CO - 1994 13 ; Burlington, VT - 1994 14 ; California Academy of Family Physicians - 1996 15 ; California Democratic Party - 1993 16 ; California Legislative Council for Older Americans - 1993 17 ; + California Medical Association - 1994 18 ; California Nurses Association - 1995 19 ; California-Pacific Annual Conference of the United Methodist Church - 1996 20 ; California Pharmacists Association - 1997 21 ; California Society of Addiction Medicine - 1997 22 ; California Voters - 1996 23 ; Cannabis Freedom Fund 1996 24 ; Colorado Voters - 2000 25 ; Colorado Nurses Association - 1995 26 ; Contigo-Conmigo - 1997 27 ; Consumer Reports Magazine - 1997 28 ; Crescent Alliance Self Help for Sickle Cell - 1999 29 ; Cure AIDS now - 1991 30 ; District of Columbia Voters - 1999 31 ; + Episcopal Church of the U.S. - 1982 32 ; Farmacy - 1999 33 ; Federation of American Scientists - 1994 34 ; Florida Governor's Red Ribbon Panel on AIDS - 1993 35 ; Florida Medical Association - 1997 36 ; Frisco, CO - 1994 37 ; Hawaii Kokua Council of Senior Citizens - 2000 38 ; Hawaii Legislature - 2000 39 ; Hawaii Nurses Association - 1999 40 ; Institute of Medicine - 1982 & 1999 41 ; International Cannabis Alliance of Researchers and Educators ICARE ; - 1992 42 ; Iowa Civil Liberties Union 43 ; Iowa Democratic Party - 1994 & 2000 44 ; Kaiser Permanente - 1997 and aldara, because buy advair.
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Any other steroid long acting beta-agonist combinations such as budesonide formoterol versus placebo or above treatments for a period of at least two weeks Types of outcome measures PRIMARY Clinical outcomes - exacerbations, urgent visits and hospitalisations SECONDARY 1 ; Change in forced expiratory volume in 1 second FEV1 ; and change in forced ventilatory capacity FVC ; : trough, peak and average; and other measures of pulmonary function 2 ; Exercise performance - six minute walk and other measures 3 ; Quality of life scales 4 ; Self-rated symptom score symptoms of breathlessness 5 ; Inhaled rescue medication used during the treatment period and other concomitant medication usage including antibiotics and steroids 6 ; "Bad days" 7 ; Area under the curve as the beta-agonist response following the first and the last morning dose of LABA ICS inhaled corticosteroids ; 8 ; Per cent of response to salbutamol from baseline FEV1, looking for tachyphylaxis 9 ; Pharmacoeconomic advantages 10 ; Adverse events palpitations, tremor, hoarseness dysphonia, oral candidiasis, cataracts, skin bruising, bone fracture, bone density, plasma cortisol level SEARCH STRATEGY FOR IDENTIFICATION OF STUDIES We searched the Cochrane Airways Group COPD register using the following terms: beta * and agonist * ; and long-acting or "long acting" ; or beta * and adrenergic * ; and long-acting or "long acting" ; and * steroid or * steroids or steroid * or fluticasone and salmeterol ; or Seretide or Qdvair ; or formoterol and budesonide ; or Symbicort ; In addition, we performed a search of LILACS all years to March 2003 ; and the Cochrane Central Register of Controlled Trials CENTRAL ; The Cochrane Library Issue 1, 2003 ; . We reviewed reference lists of all primary studies and review articles for additional references. We also contacted authors of identified randomised trials about other published and unpublished studies. In addition, we contacted Allen and Hanburys for GlaxoSmithKline GSK ; , the manufacturer of Seretide, and other manufacturers of combination therapy, regarding unpublished studies and handsearched abstracts of recent respiratory conferences European Respiratory Society ERS ; 2002, British Thoracic Society BTS ; 2002 and American Thoracic Society ATS ; 2002 and alendronate.
Salmeterol: Pregnancy Category C. No teratogenic effects occurred in rats at oral doses up to 2 mg kg approximately 160 times the maximum recommended daily inhalation dose in adults on a mg m2 basis ; . In pregnant Dutch rabbits administered oral doses of 1 mg kg and above approximately 50 times the maximum recommended daily inhalation dose in adults based on comparison of the AUCs ; , salmeterol exhibited fetal toxic effects characteristically resulting from beta-adrenoceptor stimulation. These included precocious eyelid openings, cleft palate, sternebral fusion, limb and paw flexures, and delayed ossification of the frontal cranial bones. No significant effects occurred at an oral dose of 0.6 mg kg approximately 20 times the maximum recommended daily inhalation dose in adults based on comparison of the AUCs ; . New Zealand White rabbits were less sensitive since only delayed ossification of the frontal bones was seen at an oral dose of 10 mg kg approximately 1, 600 times the maximum recommended daily inhalation dose in adults on a mg m2 basis ; . Extensive use of other beta-agonists has provided no evidence that these class effects in animals are relevant to their use in humans. There are no adequate and well-controlled studies with salmeterol in pregnant women. Salmeterol should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Salmeterol xinafoate crossed the placenta following oral administration of 10 mg kg to mice and rats approximately 410 and 810 times, respectively, the maximum recommended daily inhalation dose in adults on a mg m2 basis ; . Use in Labor and Delivery: There are no well-controlled human studies that have investigated effects of ADVAIR DISKUS on preterm labor or labor at term. Because of the potential for beta-agonist interference with uterine contractility, use of ADVAIR DISKUS during labor should be restricted to those patients in whom the benefits clearly outweigh the risks. Nursing Mothers: Plasma levels of salmeterol, a component of ADVAIR DISKUS, after inhaled therapeutic doses are very low. In rats, salmeterol xinafoate is excreted in the milk. There are no data from controlled trials on the use of salmeterol by nursing mothers. It is not known whether fluticasone propionate, a component of ADVAIR DISKUS, is excreted in human breast milk. However, other corticosteroids have been detected in human milk. Subcutaneous administration to lactating rats of 10 mcg kg tritiated fluticasone propionate less than the maximum recommended daily inhalation dose in adults on a mcg m2 basis ; resulted in measurable radioactivity in milk. Since there are no data from controlled trials on the use of ADVAIR DISKUS by nursing mothers, a decision should be made whether to discontinue nursing or to discontinue ADVAIR DISKUS, taking into account the importance of ADVAIR DISKUS to the mother. Caution should be exercised when ADVAIR DISKUS is administered to a nursing woman. Pediatric Use: Use of ADVAIR DISKUS 100 50 in patients 4 to 11 years of age is supported by extrapolation of efficacy data from older patients and by safety and efficacy data from a study of ADVAIR DISKUS 100 50 in children with asthma aged 4 to 11 years see CLINICAL TRIALS: Asthma: Pediatric Patients and ADVERSE REACTIONS: Asthma: Pediatric.
Otologic Drugs hearing or balance ; : Drugs used for the treatment or prevention of motion sickness or vertigo e.g., dimenhydrinate [Dramamine], meclizine [Antivert] ; are not acceptable. Included among those not acceptable are skin patch preparations of scopolamine Transderm Scop ; . Antibiotic or steroid topical ear preparations are acceptable if the condition does not interfere with hearing or any required use or function of earphones and equipment. Nasal Preparations: Decongestant nose drops e.g., phenylephrine [Neo-Synephrine, Vicks Sinex] oxymetazoline [Afrin], xylometazoline [Otrivin] ; , are acceptable in the absence of adverse effects. Steroid sprays e.g., fluticasone [Flonase], triamcinolone [Nasacort], budesonide [Rhinocort] ; for allergic rhinitis hay fever ; also are acceptable. Cold Remedies: There are too many OTC preparations to list individually. An ATCS should carefully read the ingredients list to determine if the remedy contains drugs that are inappropriate for safetyrelated duties. These may include barbiturates e.g., phenobarbital or other substance with "barb" in its name ; , antihistamines e.g., diphenhydramine, chlorpheniramine, doxylamine, promethazine, dexbrompheniramine, triprolidine ; , or an opiate, e.g., codeine, or hydrocodone. These drugs are not acceptable for ATCS duties. If the label includes, "Warning. May be habit-forming, " or if mentions drowsiness or caution in operating a vehicle, the ATCS should not use it. Many liquid preparations contain alcohol and may not be used while on duty: use off duty only with caution. Dextromethorphan, guaifenesin, phenylephrine, pseudoephedrine, and ephedrine are acceptable ingredients. Antihistamines: Older, sedating type antihistamines e.g., chlorpheniramine [Chlor-Trimeton, Teldrin], diphenhydramine [Benadryl] ; and the newer, but still sedating drugs like cetirizine Zyrtec ; , are not acceptable. The newer, non-sedating antihistamines e.g., fexofenadine [Allegra], loratadine [Claritin], desloratadine [Clarinex] ; including decongestant combinations, are acceptable for use by working ATCSs after review by RFS confirming the absence of adverse side effects during a brief trial of the drug. The condition must not adversely affect the ability of the ATCS to perform safely. Respiratory Drugs: Most beta-adrenergic agonists e.g., metaproteronol [Alupent], terbutaline [Brethine], albuterol [Proventil, Ventolin] ; , xanthine medications e.g., theophylline ; and cromolyn Crolom, Intal ; used for asthma or other bronchorestrictive pulmonary problems are acceptable in the usual doses and route of administration after evaluation and a trial period of use by the individual. Inhaled anti-inflammatory steroids e.g., triamcinolone [Azmacort], beclomethasone [Beclovent, Vanceril], fluticasone [Flovent], fluticasone [Advair] ; are usually acceptable if the asthma is controlled. Similarly, the newer leukotriene antagonists e.g., montelukast [Singulair], zileuton [Zyflo], zafirlukast [Acculate] ; are acceptable. Over-the-counter preparations e.g., Primatene Mist ; are also acceptable if the manufacturer's instructions are followed. Steroids: Systemic corticosteroids e.g., prednisone [Deltasone] tablets ; may be used for short periods with caution for acute problems such as asthma and allergic reactions. Long-term use for other and amlodipine.
H OW D YOU FEEL ABOUT THE SAFETY OF E P SIK? Dr. Vinciguerra: My patients who have undergone Epi-LASIK are very satisfied and surprised with their results. Most important to me, however, is the safety of having more tissue available. By only removing the corneal epithelium, Epi-LASIK leaves plenty of tissue 200 to 250m of stroma ; for ablating. With LASIK flap thicknesses as great as 200m, there might not be much tissue left. Dr. Cross: Epi-LASIK is the safest of all the corneal procedures and does not weaken the structural integrity of the cornea, unlike LASIK and even an Intralase procedure. Almost nothing can go wrong with Epi-LASIK; the worst that can happen is that the surgeon loses the epithelium and has to convert to PRK. With Epi-LASIK, the surgeon can almost do no harm. Dr. Kantor: The safety issue is paramount, because one of the main causes of patients' rejection of laser vision correction is fear. WHAT NEW RE SE ARCH ON E P SIK I S UNDERWAY? Dr. McDonald: I a principal investigator and the medical monitor for Norwood EyeCare's post-approval, 3-month US prospective study to assess the postoperative comfort and visual recovery of wavefront-guided customized myopic Epi-LASIK with the Norwood EyeCare Epikeratome. Dr. Durrie and the team of Lee Shahinian, MD, and Mark Volpicelli, MD, are also clinical investigators. Dr. Pallikaris: In this exciting study, it will be especially interesting to see how the coupling of Epi-LASIK and wavefront technology may impact visual outcomes. Dr. Camellin: Epi-LASIK has an advantage in wavefront-guided procedures, because it respects the biomechanics of the cornea and does not introduce variations into its shape.
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The first report of galactorrhea associated with prolactinoma in the pediatric age group in Thailand. Case Report A 14-year-old girl presented with bilateral nipple discharge for 4 days. Her parents were normal but the patient had congenital right hip disarticulation and left transverse femoral amputation. She had been doing well in school despite being restricted to a wheelchair. Four months prior to this admission, she had a right ovarian cyst. A cystectomy was successfully performed. She had complained of breast enlargement for 5 months but no history of administration of any potentially causative medications. She had been having normal and regular menstruation, and her last menstrual period was 10 days prior to admission. Physical examination revealed an active girl in a wheel chair, cooperative, and with normal vital signs. Pubertal staging corresponded with Tanner stage . Milk ejection was observed from the breasts with mild tenderness and without any mass. No abnormal neurologic signs or abdominal mass were found and the other findings were unremarkable. The complete blood count, urinary analysis, and blood for urea nitrogen, creatinine, electrolytes, calcium, phosphate, thyroid function tests, and fasting blood glucose level were within normal limits. A and anastrozole.
Page 5 Discourage beneficiary use of higher-cost formulary medications through strategies such as prior authorization requirements 6. Shift costs to other payers, such as requiring beneficiaries to be hospitalized to receive intravenous medications CMS regulations and oversight of PDPs are critical to protecting beneficiaries from strategies that prevent them from accessing needed and appropriate medications. CMS should anticipate the use or inappropriate application of these strategies by issuing regulations that ensure protection of Medicare beneficiaries, especially the dual eligible individuals. Organizations with an interest in becoming PDPs have expressed a desire for maximum flexibility and control, with few regulations to restrict their business practices. This would, of course, be optimal for these businesses to minimize their risk and maximize their potential for profit. On the other hand, consumer advocates have expressed concerns about the potential for these PDPs to deny access to medications, especially to dual eligibles. Without access to a wide variety of medications, and consumer protections, dual eligible individuals may lose access to critically needed medications. Medicare beneficiaries who are not dual eligibles may choose not to enroll in Part D when it becomes available. Recommendation: ASCP shares these concerns and urges CMS to include adequate consumer protections in the regulations so that Medicare beneficiaries will have access to needed and appropriate medications through the Medicare Part D program. 2.2 Medicare Advantage Prescription Drug Plans MA-PD.
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Appendix Table 3. Status and Ethnicity of Patients Requiring Modification of Treatment and atarax.
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LUNESTA and XOPENEX HFA are trademarks and XOPENEX is a registered trademark of Sepracor Inc. EmboSphere is a registered trademark of BioSphere Medical Inc. XUSAL is a trademark and XYZAL and ZYRTEC are registered trademarks of UCB, Societe Anonyme. CLARITIN, CLARINEX and PROVENTIL are registered trademarks of Schering Corporation. ALLEGRA is a registered trademark of Merrell Pharmaceuticals. PROPULSID is a registered trademark of Johnson & Johnson. SONATA is a registered trademark of Jones Pharma Incorporated, a wholly owned subsidiary of King Pharmaceuticals Inc. AMBIEN is a registered trademark of Synthelabo. ADVAIR is a registered trademark of Glaxo Group Limited. ASTELIN is a registered trademark of Carter-Wallace, Inc. NORVASC is a registered trademark of Pfizer Inc. PROZAC is a registered trademark of Eli Lilly and Company. IMOVANE and AMOBAN are registered trademarks of Rhone-Poulenc Rorer S.A and aldactone.
QUANTIFICATION OF CANINE RIGHT VENTRICULAR MOTION USING TISSUE DOPPLER IMAGING IN HEALTHY DOGS: DESCRIPTION, REPEATABILITY AND REPRODUCIBILITY. V. Chetboul1, C. Carlos1, A. Nicolle1, D. Concordet2, T. Lamour3, J. Ginesta3, V. Gouni1, J.-L. Pouchelon1, and H.P. Lefebvre.2 1Cardiology Unit of Alfort, National Veterinary School of Alfort, France. 2UMR 181 Physiopathologie et Toxicologie Experimentales INRA-ENVT, National Veterinary School of Toulouse, France. 3Base Cinophile de l'Arme de Terre, Suippes, France. Right ventricular RV ; motion is poorly documented in dogs. Although RV function is probably altered in many heart diseases involving the right and or left ventricle, its quantitative assessment has not been used for clinical investigations in canine cardiology. It would therefore be relevant to develop an accurate non-invasive method for evaluating canine regional RV function. The aim of the present study was to describe the right ventricular myocardial motion and determine the within-day repeatability ; and the between-day reproducibility ; variability of RV myocardial velocities using 2D color Tissue Doppler Imaging TDI ; in awake healthy dogs. Six healthy Beagle dogs four to seven years; 11.9 to 16.8 kg ; were used. A total of 36 2D color TDI examinations were performed by the same trained observer on four different days with three dogs examined per day at three non-consecutive times. Longitudinal RV velocities were recorded in two segments basal and apical ; of the RV myocardial wall RVMW ; using the left apical 4-chamber view. Longitudinal left ventricular free wall LVFW ; velocities were also recorded in a basal and an apical segment. A Student paired t test was used to compare the right basal and apical velocities at each phase of the cardiac cycle, and to compare LVFW and RVMW velocities at each phase of the cardiac cycle. A general linear model was used to determine the within-day and between-day coefficients of variation CV ; . As described for the LVFW, right velocity profiles included one positive systolic wave and two negative diastolic waves. The RVMW velocities were significantly higher than the LVFW velocities of the corresponding segment at each phase of the cardiac cycle in the basal segment p 0.01 ; , and in systole and late diastole in the apical segments p 0.05 ; . RVMW velocities were higher in the basal than in the apical segments p 0.001 ; , thus defining right intramyocardial velocity gradients cm s ; from the base to the apex 6.0 1.6, 6.7 and 4.7 1.1, in systole, early and late diastole, respectively ; . Most within- and between-day CV values 10 12 ; measured in the basal segment of the RVMW and LVFW were 15%, the lowest being observed in the basal segment of the RVMW 3.5% ; in early diastole. In conclusion, TDI provides a rapid and non-invasive evaluation of the systolic and diastolic RV function in the awake dog with adequate repeatability and reproducibility of the measurements particularly at the base. Further studies in canine patients are however required to determine the clinical relevance, sensitivity and specificity of these new indices of RV function.
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Modifications in the Centers for Medicare and Medicaid Services CMS ; form are required to increase the accuracy of data capture for arrhythmias and near-fatal cardiac arrest in dialysis patients. Studies are needed to assess the outcome and the effectiveness of different preventive and treatment strategies to improve the dismal outcome of near-fatal arrhythmias in dialysis patients. There is a strong need to evaluate the mechanisms of sudden death in this population.
Bernardo Lopez-Cano, Robert P. Ryan, Carol P. Moreno-Quinn, Jozef Lazar, Howard J. Jacob, Medical College of Wisconsin, Milwaukee, WI; Abraham P. Provoost, Erasmus University, Rotterdam, Netherlands; Richard J. Roman, Medical College of Wisconsin, Milwaukee, WI The Fawn-hooded hypertensive rat FHH ; is a model of systolic hypertension that develops progressive proteinuria, glomerulosclerosis and end-stage renal disease. We have previously reported that FHH rats exhibit impaired autoregulation of renal blood flow RBF ; and there is a quantitative trait loci QTL ; for proteinuria on chromosome 1 called Rf-1 in a cross of FHH and August Copenhagen Irish rats ACI ; . The present study evaluated whether impaired autoregulation of RBF in FHH rats is linked to chromosome 1 and co-localizes with the Rf-1 region that contributes to the development of renal disease. Autoregulation of RBF was compared in FHH and a consomic strain FHH.BN1 ; in which chromosome 1 from Brown-Norway BN ; was introgressed into the FHH genetic background. The autoregulation indices AI change in RBF change in perfusion pressure ; averaged 0.80 0.08 n 10 ; in FHH and 0.14 0.03 n 9 ; in FHH.BN1 rats. We next performed a genetic linkage analysis for autoregulation of RBF in 87 F2 rats generated from a backcross of FHH.BN1 and FHH rats. The results demonstrated the presence of a QTL with a LOD score of 6.31 located near marker D1Rat376. To confirm the existence of the QTL for autoregulation of RBF, two overlapping congenic strains of FHH were created. In one of the strains a small region of chromosome 1 from the BN rat between D1Rat73 to D1Rat89 including the D1Rat376 marker ; was introgressed into the FHH genetic background. Autoregulation of RBF averaged 0.14 0.03 n 7 ; in this congenic strain similar to that seen in the FHH.BN1 strain. In contrast, RBF was poorly autoregulated AI 0.65 0.07, n 4 ; in a control congenic strain in which the adjacent flanking region of the genome of the BN rat from markers D1rat183 to D1rat73 was introduced into the FHH genetic background. These results indicate that there is a gene for the impaired autoregulation of RBF that triggers elevations in glomerular capillary pressure in FHH rats during the development of hypertension between markers D1Rat73 and D1Rat89 and that this gene lies within the confidence interval of the Rf-1 QTL previously linked to the development of hypertension-induced renal disease in this strain.
Sepracor presents Brovana COPD study and inhalation data at ACCP .1 TABLE OF CONTENTS.2 CORPORATE NEWS .3 MERGERS AND ACQUISITIONS .3 Valentis sells non-core assets to Inovio .3 Connetics to merge into Stiefel.3 LAB International announces LOI in PharmaForm acquisition .3 AGREEMENTS .3 Auriga licenses products from River's Edge; makes pact with Pharmelle .3 IGI and DermWorx make dermatological development pact.4 Orexo receives licence revenue; makes development pact.4 FINANCIAL NEWS .4 Growth in Baxter's BioScience and Renal divisions offset lower Medication Delivery sales .4 International sales help Abbott keep sales momentum.5 J&J's MD&D unit records sales growth across all business in nine-month period .6 LITIGATION .6 INEX provides update on Tekmira litigation proceedings .6 PRODUCT NEWS .7 APPROVALS .7 DUSA receives Brazilian regulatory approval for Levulan .7 Altana to market its ciclesonide nasal spray in the US .7 BioLucent receives 510 k ; for APBI treatment .7 LAUNCHED PRODUCTS.7 GSK's Advaig HFA available in the US .7 R&D .8 Sirtex launches global microspheres patient registry .9 Apollo claims topical treatment for psoriasis outperforms injection counterpart.9 OGD provides recommendations for Lidoderm trial design . 10 MediVas reports positive preclinical data for HN51 flu vaccine . 11 Rockwell submits SFP dose-ranging study protocol to FDA . 11 Inovio receives further US funding for genebased vaccine development . 11 Voyager ends AD drug-delivery trial early. 11 CoreValve claims world's first 'pure' PAVR procedure using its revalving system . 12 Algeta presents Alpharadin in patients with HRPC trial data. 12 DelSite presents nasal powder flu vaccine data .12 JNIID receives encouraging vaccineenhancement platform study results .13 TORCH study data is presented at CHEST .13 Cambridge Consultants introduces new inhaler intended for pandemic use .13 Dharma completes Phase I IDDS trial.14 Starpharma's VivaGel trial begins recruitment.14 Scolr reports promising results from second osteoporosis trial .15 Shire highlights promising Phase IIIb Daytrana results .15 Elite on target for abuse deterrent product 2009 launch .16 DES NEWS . 17 Highlights from the Transcatheter Therapeutics Meeting, Washington, DC, 25th 29th October 2006 .17 The Boston Scientific slant .17 The Cordis Slant .19 A view from Abbott .21 Medtronic and the Endeavor DES .22 Debate rumbles on over long-term safety of DES .22 A TCT look at bioabsorbable biocompatible stents.23 Hydromer enters evaluation phase for polymeric stent coating .25 X-Cell and SurModics receive disappointing oestradiol-eluting stent trial results.25 CeloNova offers new DES coating option.25 MIVT to begin human implants of HAp coated stent in 2007 .26 REGULATORY FILINGS .26 Critical Therapeutics applies for NDA for controlled-release asthma drug .26 PATENTS .27 Auriga applies for multipurpose drug-delivery patent to target OTC market .27 CONFERENCE LISTINGS. 27 COMPANY INDEX . 28 Does your company issue Press Releases? Would you like them to appear in Drug Delivery Insight? Then contact your Press Office and put us on the Mailing List. Send all such releases to Healthcare espicom fax to + 44 1243 533418 or E: mail: alison coote espicom.
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